A study, led by William Cooper, at the Monroe Carell Jr. Children’s Hospital at Vanderbilt University Medical Center, found infants born to mothers who took angiotensin converting enzyme inhibitors ( ACE inhibitors ) during the first trimester of pregnancy had an increased risk of major birth defects, compared with infants whose mothers did not take these medications.

Out of 29,507 infants whose TennCare records were examined for the study, 209 were exposed to ACE inhibitors in the first trimester only. When those babies were compared to the rest of the population, including babies exposed to other types of antihypertensive medications, they had more than double the risk of major birth defects, especially of the heart and central nervous system.

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