In September 1993, William Blot et al., published in the Journal of the National Cancer Institute, a paper titled “Nutrition Intervention in Linxian China: Supplementation of specific vitamin/mineral combinations, cancer incidence and disease-specific mortality in the general population”.

The importance of this study needs to be emphasised. The population of the Linxian province of China has one of the highest rates of gastro-intestinal cancer, especially oesophageal and gastric cancer, in the world, and a persistently low intake of certain micro-nutrients. Approximately 30,000 adults aged between 40 and 70 years of age were studied over a 5-year period between 1986 and 1991. Various combinations of the following nutrients were provided:

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